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Psilocybin mushrooms produce psychoactive effects in humans very similar to the rest of the classical psychedelics such as LSD and mescaline. Most users describe the experience as an internal journey, in which they go through different phases with varying effects. The total duration of the experience is around 4 to 6 hours, depending on the dose. Physical Effects Physically, the main effects of psilocybin include dilation of the pupils and slight increases in blood pressure and heart rate , especially at high doses . Variation in blood pressure seems more related to subjective experience than to the physiological effects of psilocybin, particularly if anxiety appears. Nausea can sometimes occur, especially when mushrooms are ingested rather than pure psilocybin, and more rarely vomiting or diarrhea . Tremors, muscle discomfort and dizziness may also occur. The physical effects in general are usually mild and not significant. Psychological Effects Psychological effec